منابع مشابه
Intercellular Trafficking of VP22, a Herpes Simplex Virus Type 1 Tegument Protein
The herpes simplex virus type 1 (HSV-1) tegument protein, VP22 has been reported to have the property of intercellular transport. The previous studies have shown that following expression of a fusion protein containing VP22 it spreads to every cell in a monolayer and concentrates in the nucleus. In spite of these reports, some studies have shown that VP22 trafficking and its nucleus accumulatio...
متن کاملIntercellular delivery of a herpes simplex virus VP22 fusion protein from cells infected with lentiviral vectors.
Effective gene therapy depends on the efficient transfer of therapeutic genes and their protein products to target cells. Lentiviral vectors appear promising for virus-mediated gene delivery and long-term expression in nondividing cells. The herpes simplex virus type 1 tegument protein VP22 has recently been shown to mediate intercellular transport of proteins, raising the possibility that it m...
متن کاملThe Study of the Intercellular Trafficking of the Fusion Proteins of Herpes Simplex Virus Protein VP22
BACKGROUND Genetic modifications can improve the therapeutic efficacy of mesenchymal stem cell (MSC) transplantation in myocardial infarction. However, so far, the efficiency of MSC modification is very low. Seeking for a more efficient way of MSC modification, we investigated the possibility of employing the intercellular trafficking capacity of the herpes simplex virus type-1 tegument protein...
متن کاملIntercellular trafficking of VP22, a herpes simplex virus type 1 tegument protein.
BACKGROUND The herpes simplex virus type 1 (HSV-1) tegument protein, VP22 has been reported to have the property of intercellular transport. The previous studies have shown that following expression of a fusion protein containing VP22; it spreads to every cell in a monolayer and concentrates in the nucleus. In spite of these reports, some studies have shown that VP22 trafficking and its nucleus...
متن کاملintercellular trafficking of vp22, a herpes simplex virus type 1 tegument protein
the herpes simplex virus type 1 (hsv-1) tegument protein, vp22 has been reported to have the property of intercellular transport. the previous studies have shown that following expression of a fusion protein containing vp22 it spreads to every cell in a monolayer and concentrates in the nucleus. in spite of these reports, some studies have shown that vp22 trafficking and its nucleus accumulatio...
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ژورنال
عنوان ژورنال: The Journal of Gene Medicine
سال: 1999
ISSN: 1099-498X,1521-2254
DOI: 10.1002/(sici)1521-2254(199907/08)1:4<275::aid-jgm44>3.0.co;2-m